Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts
Neuropathy and bone deformities, lifelong sequelae Duster of leprosy that persist after treatment, result in significant impairment to patients and compromise their social rehabilitation.Phosphate-regulating gene with homologies to endopeptidase on the X chromosome (PHEX) is a Zn-metalloendopeptidase, which is abundantly expressed in osteoblasts an